CHEM 3381: Majors Laboratory for Organic Chemistry II
This lab course is for chemistry majors. Non-chemistry majors can also take this course if they wish. This course meets twice a week and is worth 2 credit hours.
This new version of CHEM 3381 is a continuation of the nonmajors organic 1 lab (CHEM 3321) and nonmajors organic 2 lab (CHEM 3341). Techniques learned in 3321/3341 are expanded upon in more detail, and new techniques are covered including new methods of characterization, microwave chemistry, large-scale column chromatography, and literature searches. Many new reactions are performed, including Grubbs metathesis and palladium coupling. The capstone project for this course is a four-week independent synthesis project chosen by the students, following a procedure from literature. You will write a paper about your synthesis and present your work to the class.
The course syllabus and TA office hours and emails are available on this website. Course documents will be posted on Canvas.
List of Sections
| Lab | Day | Time | Location | TA |
| 401 | Tue/Thu | 10:10 AM-1:00 PM | EKLC M1B35 | Timmy Davis |
Experiment Schedule
| Dates | # | Experiment |
| Tue Aug 27 | No labs | |
| Thu Aug 29 | Syllabus, Check-In & NMR review | |
| Tue Sep 3 | 25 | Recrystallization of an Unknown |
| Thu Sep 5 | 26 | Chemical Literature |
| Tue Sep 10 | 27 | Aromatic Iodination |
| Thu Sep 12 | 28 | Advanced Spectroscopy |
| Tue Sep 17 | 29 | Isolation of Caffeine |
| Thu Sep 19 | 30 | Computational Chemistry |
| Tue Sep 24 | 31 | Large-Scale Column Chromatography (set up for projects) |
| Thu Sep 26 | 32 | Alkyne Formation |
| Tue Oct 1 | 33 | Substitution Kinetics (Synthesis Proposal and Materials Request due) |
| Thu Oct 3 | 34 | Oxidation of a Diol (set up for Grubbs) |
| Tue Oct 8 | 35 | Grubbs Metathesis |
| Thu Oct 10 | 36 | Palladium Coupling |
| Tue Oct 15 | 37 | Aromatic Multistep Synthesis, day 1 |
| Thu Oct 17 | 37 | Aromatic Multistep Synthesis, day 2 |
| Tue Oct 22 | 38 | Nucleophilic Aromatic Substitution |
| Thu Oct 24 | 39 | Coumarin Dyes (set up for Frambinone) |
| Tue Oct 29 | 40 | Synthesis of Frambinone, day 1 |
| Thu Oct 31 | 40 | Synthesis of Frambinone, day 2 (set up for projects) |
| Tue Nov 5 | 41 | Multistep Synthesis Project, day 1 |
| Thu Nov 7 | 41 | Multistep Synthesis Project, day 2 |
| Tue Nov 12 | 41 | Multistep Synthesis Project, day 3 |
| Thu Nov 14 | 41 | Multistep Synthesis Project, day 4 |
| Tue Nov 19 | 41 | Multistep Synthesis Project, day 5 |
| Thu Nov 21 | 41 | Multistep Synthesis Project, day 6 |
| Tue Nov 26 | No labs | |
| Thu Nov 28 | No labs | |
| Tue Dec 3 | 41 | Multistep Synthesis Presentations |
| Thu Dec 5 | 41 | Multistep Synthesis Presentations, Final Quiz & Check-Out |
| Tue Dec 10 | No labs | |
| Thu Dec 12 | No labs |