CHEM 3381: Majors Laboratory for Organic Chemistry II
This lab course is for chemistry majors. Non-chemistry majors can also take this course if they wish. This course meets twice a week and is worth 2 credit hours.
This new version of CHEM 3381 is a continuation of the nonmajors organic 1 lab (CHEM 3321) and nonmajors organic 2 lab (CHEM 3341). Techniques learned in 3321/3341 are expanded upon in more detail, and new techniques are covered including new methods of characterization, microwave chemistry, large-scale column chromatography, and literature searches. Many new reactions are performed, including Grubbs metathesis and palladium coupling. The capstone project for this course is a four-week independent synthesis project chosen by the students, following a procedure from literature. You will write a paper about your synthesis and present your work to the class.
The course syllabus and TA office hours and emails are available on this website. Course documents will be posted on Canvas.
List of Sections
| Lab | Day | Time | Location | TA |
| 401 | Tue/Thu | 10:10 AM-1:00 PM | EKLC M1B35 | Austin Bargmann |
Experiment Schedule
| Dates | # | Experiment |
| Tue Aug 29 | No labs | |
| Thu Aug 31 | Syllabus & NMR review (remote) | |
| Tue Sep 5 | 25 | Check-In & Recrystallization of an Unknown |
| Thu Sep 7 | 26 | TLC of Reactions |
| Tue Sep 12 | 27 | Advanced Spectroscopy |
| Thu Sep 14 | 28 | Chemical Literature |
| Tue Sep 19 | 29 | Computational Chemistry |
| Thu Sep 21 | 30 | Isolation of Natural Products |
| Tue Sep 26 | 31 | Large-Scale Column Chromatography (Start planning for synthesis projects) |
| Thu Sep 28 | 32 | Alkyne Formation |
| Tue Oct 3 | 33 | Halogenation of Alkanes (Synthesis Proposal and Materials Request due) |
| Thu Oct 5 | 34 | Substitution Kinetics |
| Tue Oct 10 | 35 | Oxidation of a Diol (set up for Grubbs) |
| Thu Oct 12 | 36 | Grubbs Metathesis |
| Tue Oct 17 | 37 | Palladium Coupling |
| Thu Oct 19 | 38 | Aromatic Multistep Synthesis |
| Tue Oct 24 | 39 | Nucleophilic Aromatic Substitution |
| Thu Oct 26 | 40 | Coumarin Dyes (set up for Frambinone) |
| Tue Oct 31 | 41 | Synthesis of Frambinone, day 1 |
| Thu Nov 2 | 41 | Synthesis of Frambinone, day 2 |
| Tue Nov 7 | 42 | Multistep Synthesis Project, day 1 |
| Thu Nov 9 | 42 | Multistep Synthesis Project, day 2 |
| Tue Nov 14 | 42 | Multistep Synthesis Project, day 3 |
| Thu Nov 16 | 42 | Multistep Synthesis Project, day 4 |
| Tue Nov 21 | No labs | |
| Thu Nov 23 | No labs | |
| Tue Nov 28 | 42 | Multistep Synthesis Project, day 5 |
| Thu Nov 30 | 42 | Multistep Synthesis Project, day 6 |
| Tue Dec 5 | 42 | Multistep Synthesis Presentations |
| Thu Dec 7 | 42 | Multistep Synthesis Presentations, Final Quiz & Check-Out |
| Tue Dec 12 | No labs | |
| Thu Dec 14 | No labs |