CHEM 3361: Majors Laboratory for Organic Chemistry I
This lab course is for chemistry majors. Biochemistry majors are encouraged, but not required, to take this course. Non-chemistry majors can also take this course if they wish. This course meets twice a week and is worth 2 credit hours.
A large part of Chem 3361 is spent learning the theory behind and practicing the techniques of organic chemistry: chromatography, distillation, extraction, and crytallization. Since the labs meet twice as often as Chem 3321, this course goes into more depth and provides more practice in these techniques than does the non-majors course. Once the techniques are mastered, they are applied to study reactions in organic chemistry, including addition to carbonyls, acyl substitution, elimination, stereochemistry of alkene additions, reduction, and oxidation. Both IR and NMR spectroscopy are studied and applied to the identification of unknown compounds. Two laboratory periods are devoted to working with molecular model sets to study nomenclature, conformational analysis, and stereochemistry.
- 3361 Course Syllabus, Schedule and Policies
- Lab report rubric (attach a copy to each lab report)
- Identification of Unknowns rubric
- Example lab report
- Drawer check-in sheet and contract
- Makeup Lab Scheduler
- Cleanup points
TA office hours and emails are posted here.
|301||MW||1:00 PM||EKLC M1B65||Ethan Miller|
|311||MW||5:00 PM||EKLC M1B65||Matthew Farmer|
|321||TR||8:00 AM||EKLC M1B65||Thomas Carey|
|331||TR||11:00 AM||EKLC M1B65||Garrett Cairo|
Schedule for Spring 2017
|Jan 16-20||Labs will not meet|
|Jan 23-24||Lab Check-in & Exp. 1: Lab Safety, ChemDraw & Excel||Experiment Manual; laptop if you have one||Yes||Be sure to read the safety chapter in the handbook before lab. In case you haven't purchased the lab books yet,
Experiment 1 and the safety chapter are available as PDFs.
This Lab Safety Movie may also help.
You can also save time by downloading and installing ChemDraw ahead of time.
|Jan 25-26||Exp. 2: Thin Layer Chromatography and Melting Point||Prelab||Yes (SQ Answers)||Experiment 2 is available as a PDF.
This is the first experiment this term that has a full lab report associated with it. Be sure to print a copy of the lab report rubric and attach it to your lab report when you turn it in at the next lab session.
TLC procedure and more
Melting point movie (10:45 into the Crystallization movie)
|Jan 30-31||Exp. 3: IR Spectroscopy & Modeling Conformations||(nothing)||No||Experiment 3 is available as a PDF.
You can check out a model set if you don't have one.
|Feb 1-2||Exp. 4: Extraction||Prelab||Yes (SQ Answers)||Extraction procedure
Remember to save the product from this lab for the next lab.
|Feb 6-7||Exp. 5: Recrystallization||Prelab||Yes (SQ Answers)||Recrystallization movie
|Feb 8-9||Exp. 6: NMR Spectroscopy||(nothing)||No||Chapters 18 & 20 in the Lab Handbook and Chapter 13 in Loudon;
Spectroscopy Tutorial and
NMR Theory Tutorial on this web site.
The in-class Spectroscopy Worksheet (in the experiment manual) is due before you leave today. The Spectroscopy Homework is due in one week. Download this file and print the pages you are assigned.
|Feb 13-14||Exp. 25: Recrystallization of an Unknown||Prelab||Yes (SQ Answers)|
|Feb 15-16||Exp. 7: Practical NMR||Completed Spectroscopy Homework and laptop if you have one||Yes||You will need to download and install MestreNova. NMR data files can be downloaded for this lab.|
|Feb 20-21||Exp. 26: TLC of Reactions||Prelab||Yes (SQ Answers)|
|Feb 22-24||Exp. 9: Distillation||Prelab||Yes (SQ Answers)||Distillation procedure GC Movie|
|Feb 27-28||Exp. 18: Microscale Column Chromatography||Prelab||Yes (SQ Answers)||See the section on how to run a flash column in the Column Chromatography Section.|
|Mar 1-2||Exp. 27: Advanced Spectroscopy||Laptop if you have one||No|
|Mar 6-7||Exp. 18: Identification of Unknowns, day 1||Prelab||Yes (SQ Answers)||Identification of Unknowns rubric
A visual guide to this lab
NMR spectra for all compounds
|Mar 8-9||Exp. 18: Identification of Unknowns, day 2||(nothing)||No||The ID of Unknowns paper is due three lab periods from now.|
|Mar 13-14||Exp. 8: Isolation of Limonene||Prelab and worksheet||No||You will need the Handbook supplements on Green Chemistry and Optical Activity and Polarimetry.|
|Mar 15-16||Exp. 28: Chemical Literature||Laptop if you have one||No||Make sure to request a SciFinder account before the lab.|
|Mar 20-21||Exp. 20: Reduction of Ketones||Prelab||Yes (SQ Answers)|
|Mar 22-23||Exp. 29: Computational Chemistry||Laptop if you have one||No||You can download and install the modelling programs, or they will be available on laptops in lab.|
|Mar 27-31||Labs will not meet|
|Apr 3-4||Exp. 30: Isolation of Caffeine, day 1||Prelab||No||You will need to get the cited papers and compile your own procedure.|
|Apr 5-6||Exp. 30: Isolation of Caffeine, day 2|
|Apr 10-11||Exp. 21: Grignard Dyes||Prelab||Yes (SQ Answers)||You will need the Handbook supplement on UV-Visible and Fluorescence Spectroscopy.|
|Apr 12-13||Exp. 22: Liquid Crystals||Prelab, ID of Unknowns paper||Yes (SQ Answers)|
|Apr 17-18||Exp. 10: Stereochemistry of Alkene Additions||Prelab and worksheet||No||Instead of a prelab quiz, fill in the worksheet included with the lab.
You will need the Handbook supplement on Green Chemistry.
|Apr 19-20||Exp. 11: Modelling Chirality & Cycloalkanes||No||You can check out a model set if you don't have one.|
|Apr 24-25||Exp. 12: Regiochemistry of Eliminations||Prelab and worksheet||No||You can download the NMR spectrum for 3-methylcyclohexene.|
|Apr 26-27||Exp. 13: Oxidation of Alcohols||Prelab||Yes (SQ Answers)|
|May 1-2||Lab Check-out & Final Quiz||Buff Onecard||Yes||For the final quiz, you should review the study questions, worksheets and prelab quizzes.|