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CHEM 3361: Majors Laboratory for Organic Chemistry I

This lab course is for chemistry majors. Biochemistry majors are encouraged, but not required, to take this course. Non-chemistry majors can also take this course if they wish. This course meets twice a week and is worth 2 credit hours.

A large part of Chem 3361 is spent learning the theory behind and practicing the techniques of organic chemistry: chromatography, distillation, extraction, and crytallization. Since the labs meet twice as often as Chem 3321, this course goes into more depth and provides more practice in these techniques than does the non-majors course. Once the techniques are mastered, they are applied to study reactions in organic chemistry, including addition to carbonyls, acyl substitution, elimination, stereochemistry of alkene additions, reduction, and oxidation. Both IR and NMR spectroscopy are studied and applied to the identification of unknown compounds. Two laboratory periods are devoted to working with molecular model sets to study nomenclature, conformational analysis, and stereochemistry.

TA office hours and emails are posted here.

301MW1:00 PMEKLC M1B65Ethan Miller
311MW5:00 PMEKLC M1B65Matthew Farmer
321TR8:00 AMEKLC M1B65Thomas Carey
331TR11:00 AMEKLC M1B65Garrett Cairo

Schedule for Spring 2017

Dates Experiment Bring Quiz Notes
Jan 16-20 Labs will not meet
Jan 23-24 Lab Check-in & Exp. 1: Lab Safety, ChemDraw & Excel Experiment Manual; laptop if you have one Yes Be sure to read the safety chapter in the handbook before lab. In case you haven't purchased the lab books yet, Experiment 1 and the safety chapter are available as PDFs. This Lab Safety Movie may also help.
You can also save time by downloading and installing ChemDraw ahead of time.
Jan 25-26 Exp. 2: Thin Layer Chromatography and Melting Point Prelab Yes (SQ Answers) Experiment 2 is available as a PDF.
This is the first experiment this term that has a full lab report associated with it. Be sure to print a copy of the lab report rubric and attach it to your lab report when you turn it in at the next lab session.
TLC procedure and more
Melting points
Melting point movie (10:45 into the Crystallization movie)
Jan 30-31 Exp. 3: IR Spectroscopy & Modeling Conformations (nothing) No Experiment 3 is available as a PDF.
IR Tutorial
You can check out a model set if you don't have one.
Feb 1-2 Exp. 4: Extraction Prelab Yes (SQ Answers) Extraction procedure
Extraction movie
Remember to save the product from this lab for the next lab.
Feb 6-7 Exp. 5: Recrystallization Prelab Yes (SQ Answers) Recrystallization movie
Recrystallization procedure
Feb 8-9 Exp. 6: NMR Spectroscopy (nothing) No Chapters 18 & 20 in the Lab Handbook and Chapter 13 in Loudon; Spectroscopy Tutorial and NMR Theory Tutorial on this web site.
The in-class Spectroscopy Worksheet (in the experiment manual) is due before you leave today. The Spectroscopy Homework is due in one week. Download this file and print the pages you are assigned.
Feb 13-14 Exp. 25: Recrystallization of an Unknown Prelab Yes (SQ Answers)
Feb 15-16 Exp. 7: Practical NMR Completed Spectroscopy Homework and laptop if you have one Yes You will need to download and install MestreNova. NMR data files can be downloaded for this lab.
Feb 20-21 Exp. 26: TLC of Reactions Prelab Yes (SQ Answers)
Feb 22-24 Exp. 9: Distillation Prelab Yes (SQ Answers) Distillation procedure GC Movie
Feb 27-28 Exp. 18: Microscale Column Chromatography Prelab Yes (SQ Answers) See the section on how to run a flash column in the Column Chromatography Section.
Mar 1-2 Exp. 27: Advanced Spectroscopy Laptop if you have one No
Mar 6-7 Exp. 18: Identification of Unknowns, day 1 Prelab Yes (SQ Answers) Identification of Unknowns rubric
A visual guide to this lab
NMR spectra for all compounds
Mar 8-9 Exp. 18: Identification of Unknowns, day 2 (nothing) No The ID of Unknowns paper is due three lab periods from now.
Mar 13-14 Exp. 8: Isolation of Limonene Prelab and worksheet No You will need the Handbook supplements on Green Chemistry and Optical Activity and Polarimetry.
Mar 15-16 Exp. 28: Chemical Literature Laptop if you have one No Make sure to request a SciFinder account before the lab.
Mar 20-21 Exp. 20: Reduction of Ketones Prelab Yes (SQ Answers)
Mar 22-23 Exp. 29: Computational Chemistry Laptop if you have one No You can download and install the modelling programs, or they will be available on laptops in lab.
Mar 27-31 Labs will not meet
Apr 3-4 Exp. 30: Isolation of Caffeine, day 1 Prelab No You will need to get the cited papers and compile your own procedure.
Apr 5-6 Exp. 30: Isolation of Caffeine, day 2
Apr 10-11 Exp. 21: Grignard Dyes Prelab Yes (SQ Answers) You will need the Handbook supplement on UV-Visible and Fluorescence Spectroscopy.
Apr 12-13 Exp. 22: Liquid Crystals Prelab, ID of Unknowns paper Yes (SQ Answers)
Apr 17-18 Exp. 10: Stereochemistry of Alkene Additions Prelab and worksheet No Instead of a prelab quiz, fill in the worksheet included with the lab.
You will need the Handbook supplement on Green Chemistry.
Apr 19-20 Exp. 11: Modelling Chirality & Cycloalkanes No You can check out a model set if you don't have one.
Apr 24-25 Exp. 12: Regiochemistry of Eliminations Prelab and worksheet No You can download the NMR spectrum for 3-methylcyclohexene.
Apr 26-27 Exp. 13: Oxidation of Alcohols Prelab Yes (SQ Answers)
May 1-2 Lab Check-out & Final Quiz Buff Onecard Yes For the final quiz, you should review the study questions, worksheets and prelab quizzes.